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2025-26 College Football Playoff semifinal predictions, picks, odds

2025-26-college-football-playoff-semifinal-predictions,-picks,-odds
2025-26 College Football Playoff semifinal predictions, picks, odds
Indiana head coach Curt Cignetti
Indiana head coach Curt Cignetti AP

Two years ago, Indiana was still a Big Ten laughingstock, coming off a three-win season, which marked their 26th losing campaign in 29 years. One year ago, the Hoosiers were widely considered frauds, riding an exceptionally soft schedule to their first double-digit win season in program history and an unlikely playoff berth.

Now, they are unquestionably the team to beat.

No. 1 Indiana (14-0) isn’t unstoppable, but anyone picking against second-year coach Curt Cignetti at this point is choosing to ignore their eyes and focus on history that is no longer relevant.

No. 5 Oregon (13-1) has more blue chippers than the nation’s top-ranked team, a top-10 offense, a top-five defense and two losses in the past two calendar years. But the Ducks’ Oct. 11 defeat demonstrated how the Hoosiers could overcome any disadvantage, snapping Oregon’s 18-game home winning streak, 30-20, despite a subpar performance from Heisman winner Fernando Mendoza, who threw a game-tying pick-six in the fourth quarter.

This season, Dante Moore has faced three top-10 defenses and thrown for an average of 177 yards, with one touchdown and four interceptions. Against Indiana, the Ducks quarterback — who has thrown four interceptions in the past four games — was picked off twice and sacked six times.

Oregon quarterback Dante Moore
Oregon quarterback Dante Moore Sam Navarro-Imagn Images

“You can say I was seeing ghosts out there,” Moore said this week, channeling Sam Darnold.

Moore will likely be haunted by this semifinal for years, facing a second-ranked Hoosiers defense that has allowed a total of 13 points in its past two games (Alabama, Ohio State) despite facing more talented teams on paper. Should Oregon prevail, it will not be because Indiana — ranked top five in the nation in fewest turnovers and fewest penalties — beat themselves.

The pick: Indiana (-3.5)


Betting on College Football?


Indiana-Oregon Peach Bowl staff picks

Chris Shaw: Indiana

Howie Kussoy: Indiana

Zach Braziller: Indiana

Ted Holmlund: Oregon

Erich Richter: Indiana

Stitches: Oregon

Ethan Sears: Indiana

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