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NFL Week 1 lines, odds for all 16 games following schedule release

nfl-week-1-lines,-odds-for-all-16-games-following-schedule-release
NFL Week 1 lines, odds for all 16 games following schedule release

Week 1 NFL lines are out in May and surely someone is ready to place their bets on who will start their season off right.

The regular season’s opening game will be Sept. 4 on “Thursday Night Football” when the defending Super Bowl champion Eagles host the division rival Cowboys.

Philadelphia opens as a seven-point favorite in a potential shootout, while Dallas is +280 on the moneyline at BetMGM Sportsbook.

There will also be a Friday contest during Week 1 for the second straight year as the Chiefs are 2.5-point favorites against Jim Harbaugh’s Chargers for their clash in Brazil.

The reigning champions in each conference get a showcase game in prime time to open the season before a 13-game onslaught Sunday.

Patrick Mahomes looks to fix the offense after a slow scoring season in 2024.

Patrick Mahomes needs better offensive line play in 2025. AP

Week 1 NFL lines, odds

Cowboys vs. Eagles

Spread Moneyline Total
DAL: +7 (-110)
PHI: -7 (-110)
DAL: +280
PHI: -325
Over 46.5 (-110)
Under 46.5 (-110)

Chiefs vs. Chargers (Brazil)

Spread Moneyline Total
KC: -2.5 (-115)
LAC: +2.5 (-105)
KC: -150
LAC: +125
Over 44.5 (-110)
Under 44.5 (-110)

Cardinals vs. Saints

Spread Moneyline Total
AZ: -4.5 (-110)
NO: +4.5 (-110)
AZ: -200
NO: +165
Over 41.5 (-110)
Under 41.5 (-110)

Buccaneers vs. Falcons

Spread Moneyline Total
TB: -1.5 (-115)
ATL: +1.5 (-105)
TB -125
ATL +105
Over 48.5 (-110)
Under 48.5 (-110)

Panthers vs. Jaguars

Spread Moneyline Total
CAR: +3 (-110)
JAX: -3 (-110)
CAR (+125)
JAX (-150)
Over 46.5 (-110)
Under 46.5 (-110)

Joe Burrow needs some defensive help if he is to see serous time as a contender.

Joe Burrow needs some defensive help if he is to see serous time as a contender. AP

Bengals vs. Browns

Spread Moneyline Total
Bengals: -5.5 (-110)
Browns: +5.5 (-110)
Bengals -250
Browns +200
Over 45.5 (-110)
Under 45.5 (-110)

Dolphins vs. Colts

Spread Moneyline Total
MIA: +1.5 (-110)
IND: -1.5 (-110)
MIA -105
IND -115
Over 45.5 (-110)
Under 45.5 (-110)

Giants vs. Commanders

Spread Moneyline Total
NYG: +7 (-110)
WAS: -7 (-110)
NYG +270
WAS -350
Over 45.5 (-110)
Under 45.5 (-110)

Brian Daboll is fighting for his job in 2025.

Brian Daboll is fighting for his job in 2025. Robert Sabo for NY Post

Steelers vs. Jets

Spread Moneyline Total
PIT: -3 (-110)
NYJ: +3 (-110)
PIT -155
NYJ +130
Over 39.5 (-110)
Under 39.5 (-110)

Raiders vs. Patriots

Spread Moneyline Total
LV: +2.5 (-110)
NE: -2.5 (-110)
LV +120
NE -140
Over 43.5 (-110)
Under 43.5 (-110)

Titans vs. Broncos

Spread Moneyline Total
TEN: +7 (-110)
DEN -7 (-110)
TEN +280
DEN -350
Over 41.5 (-110)
Under 41.5 (-110)

49ers vs. Seahawks

Spread Moneyline Total
SF: -1.5 (-115)
SEA: +1.5 (-105)
SF -125
SEA +105
Over 45.5 (-110)
Under 45.5 (-110)

Lions vs. Packers

Spread Moneyline Total
DET: -1.5 (-105)
GB: +1.5 (-115)
DET (-115)
GB (-105)
Over 49.5 (-110)
Under 49.5 (-110)

Texans vs. Rams

Spread Moneyline Total
HOU: +2.5 (-105)
LAR: -2.5 (-115)
HOU +125
LAR -150
Over 46.5 (-110)
Under 46.5 (-110)

Ravens vs. Bills

Spread Moneyline Total
BAL: +1.5 (-110)
BUF: -1.5 (-110)
BAL +105
BUF -125
Over 51.5 (-110)
Under 51.5 (-110)

Betting on the NFL?


Vikings vs. Bears

Spread Moneyline Total
MIN: -1.5 (-105)
CHI: +1.5 (-115)
MIN -115
CHI -105
Over 44.5 (-110)
Under 44.5 (-110)

Why Trust New York Post Betting

Erich Richter is a brazilian jiu-jitsu blue belt but he has a black belt in MMA betting. During the football season he’s showcased massive profits at The Post in the player prop market the last two seasons. While constantly betting long shots, his return on investment is 30.15 percent since 2022.

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